Format

Send to

Choose Destination
See comment in PubMed Commons below
Epilepsy Behav. 2013 Jan;26(1):114-7. doi: 10.1016/j.yebeh.2012.10.014. Epub 2012 Dec 12.

Tobacco habits in nocturnal frontal lobe epilepsy.

Author information

1
IRCCS Istituto delle Scienze Neurologiche Bologna, and Dipartimento di ScienzeBiomediche e NeuroMotorie, Alma Mater Studiorum Università di Bologna, Bologna, Italy.

Abstract

The beneficial effect of nicotine has been reported in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) patients, but not tested in sporadic cases. Recently, a nicotine defect in the arousal pathway has been hypothesized even in sporadic NFLE patients and their relatives. This case-control family study was designed to test whether NFLE subjects were more likely to use tobacco than controls, as an indirect marker of cholinergic arousal system dysregulation. At least four relatives were included for each NFLE proband and control. Each subject was questioned about tobacco habits; 434 individuals were recruited. Moreover, we compared NFLE patients with age- and sex-matched controls to determine whether they are more likely to use tobacco. We found a slightly higher trend of tobacco use in NFLE probands compared to that in control subjects; we did not find any significant difference in the distribution of tobacco use among NFLE group compared to that in the control group.

PMID:
23246147
DOI:
10.1016/j.yebeh.2012.10.014
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center