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J Neurol Sci. 2013 Feb 15;325(1-2):183-5. doi: 10.1016/j.jns.2012.10.012. Epub 2012 Dec 13.

Multiple cerebral infarcts and intravascular central nervous system lymphoma: a rare but potentially treatable association.

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  • 1Neurology Department, Hospital de Santo António, Centro Hospitalar do Porto, Porto, Portugal.


Intravascular large B-cell lymphoma (IVLBCL) is a rare lymphoproliferative disorder characterized by massive intravascular growth of lymphoma cells with a predilection for the central nervous system (CNS). Diagnosis is generally delayed by variable clinical presentation and nonspecific laboratory findings. Brain biopsy is the gold standard diagnostic test. Prognosis is poor with a high mortality rate. We report a case of "in vivo" diagnosis of IVLBCL presenting with rapidly progressive encephalopathy secondary to multiple cerebral infarcts. This case highlights IVLBCL as a possible cause of unexplained multifocal and recurrent strokes. Earlier diagnosis and consequent earlier treatment may be associated with better prognosis.

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