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Trends Cardiovasc Med. 2013 Feb;23(2):39-45. doi: 10.1016/j.tcm.2012.08.009. Epub 2012 Dec 13.

Advances in nanotechnology for the management of coronary artery disease.

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1
Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Nanotechnology holds tremendous potential to advance the current treatment of coronary artery disease. Nanotechnology may assist medical therapies by providing a safe and efficacious delivery platform for a variety of drugs aimed at modulating lipid disorders, decreasing inflammation and angiogenesis within atherosclerotic plaques, and preventing plaque thrombosis. Nanotechnology may improve coronary stent applications by promoting endothelial recovery on a stent surface utilizing bio-mimetic nanofibrous scaffolds, and also by preventing in-stent restenosis using nanoparticle-based delivery of drugs that are decoupled from stents. Additionally, nanotechnology may enhance tissue-engineered graft materials for application in coronary artery bypass grafting by facilitating cellular infiltration and remodeling of a graft matrix.

PMID:
23245913
PMCID:
PMC3566293
DOI:
10.1016/j.tcm.2012.08.009
[Indexed for MEDLINE]
Free PMC Article
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