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Antioxid Redox Signal. 2013 Jun 1;18(16):2029-74. doi: 10.1089/ars.2012.4729. Epub 2013 Feb 19.

Mitochondria as a source of reactive oxygen and nitrogen species: from molecular mechanisms to human health.

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Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.


Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and damaging pathways in different tissues. In addition, mitochondria are an important target of reactive oxygen and nitrogen species. Here, we discuss basic mechanisms of mitochondrial oxidant generation and removal and the main factors affecting mitochondrial redox balance. We also discuss the interaction between mitochondrial reactive oxygen and nitrogen species, and the involvement of these oxidants in mitochondrial diseases, cancer, neurological, and cardiovascular disorders.

[Indexed for MEDLINE]

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