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Immun Ageing. 2012 Dec 18;9(1):28. doi: 10.1186/1742-4933-9-28.

Early dysregulation of the memory CD8+ T cell repertoire leads to compromised immune responses to secondary viral infection in the aged.

Author information

1
Trudeau Institute, Saranac Lake, NY, USA. woody@keystonesymposia.org.

Abstract

BACKGROUND:

Virus-specific memory CD8+ T cells persist long after infection is resolved and are important for mediating recall responses to secondary infection. Although the number of memory T cells remains relatively constant over time, little is known about the overall stability of the memory T cell pool, particularly with respect to T cell clonal diversity. In this study we developed a novel assay to measure the composition of the memory T cell pool in large cohorts of mice over time following respiratory virus infection.

RESULTS:

We find that the clonal composition of the virus-specific memory CD8+ T cell pool begins to change within months of the initial infection. These early clonal perturbations eventually result in large clonal expansions that have been associated with ageing.

CONCLUSIONS:

Maintenance of clonal diversity is important for effective long-term memory responses and dysregulation of the memory response begins early after infection.

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