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Oncoimmunology. 2012 Nov 1;1(8):1430-1432.

A new dynamic model of three cell interactions for CTL responses.

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Research Unit; Saskatchewan Cancer Agency; Saskatoon, SK Canada ; Department of Oncology; University of Saskatchewan; Saskatoon, SK Canada.


The exact mechanisms of CD4 help in the generation of memory cytotoxic T lymphocytes (CTLs) remain largely illusive. We propose that dendritic cells (DCs) first interact with CD4(+) T cells, resulting in DC licensing and CD4(+) T-cell priming. Thereafter, CD8(+) T cells can receive stimulatory signals from DC-CD4(+) T-cell clusters and as well as individually from licensed DCs and primed CD4(+) T cells.

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