Send to

Choose Destination
See comment in PubMed Commons below
Oncoimmunology. 2012 Nov 1;1(8):1411-1413.

Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis.

Author information

Department of Medicine; Division of Oncology; Washington University School of Medicine; St. Louis, MO USA.


Paracrine Hedgehog (Hh) signaling, in which tumor-derived Hh ligands activate stromal cells, has been implicated in the development and progression of many cancers. Recent data suggest that Hh-targeted therapeutics exert direct effects on host cells, thus interrupting a "vicious cycle" to bone metastasis that involves osteoblasts, osteoclasts, and tumor cells.

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Support Center