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Oncoimmunology. 2012 Nov 1;1(8):1409-1410.

NY-ESO-1 expression in sarcomas: A diagnostic marker and immunotherapy target.

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Laboratory of Pathology; National Cancer Institute; NIH; Bethesda, MD USA.


NY-ESO-1 (CTAG 1B) is highly expressed in the majority of synovial sarcomas and myxoid/round cell liposarcomas as well as in a subset of melanomas, but only rarely in other mesenchymal tumors. This points to a potential for using NY-ESO-1 in the differential diagnosis of these lesions. Furthermore, promising results have been obtained in clinical trials testing NY-ESO-1-targeted immunotherapy in subsets of melanoma and synovial sarcoma patients.

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