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Oncoimmunology. 2012 Nov 1;1(8):1401-1403.

Targeting cancer stem cells via dendritic-cell vaccination.

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Department of Internal Medicine; University of Michigan; Ann Arbor, MI USA.


Using syngeneic murine tumor models established in immunocompetent hosts, we showed that cancer stem cells are immunogenic and can be selectively targeted by dendritic cell-based vaccines. This new approach induced both humoral and cellular immune responses and conferred significantly superior antitumor immunity as compared with conventional vaccines.

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