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J Clin Sleep Med. 2012 Dec 15;8(6):693-7. doi: 10.5664/jcsm.2266.

Vitamin D, race, and excessive daytime sleepiness.

Author information

1
Division of Sleep Medicine, Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA. dmcca1@lsuhsc.edu

Abstract

STUDY OBJECTIVES:

First, to determine whether serum vitamin D levels were correlated with excessive daytime sleepiness (EDS) in patients with or without vitamin D deficiency (VitDd). Second, to assess whether race affected the relation between vitamin D levels and EDS.

METHODS:

Serum 25-hydroxyvitamin D (25OHD) was measured by immunoassay in a consecutive series of 81 sleep clinic patients who complained of sleep problems and nonspecific pain (25OHD < 20 ng/mL ' VitDd). Sleepiness was determined using the Epworth Sleepiness Scale score ([ESSs] ESSs ≥ 10 ≡ EDS). Correlations were assessed using Pearson r.

RESULTS:

In patients without VitDd (25OHD ≥ 20 ng/mL), ESSs was inversely correlated with vitamin D concentration (r = 0.45, p < 0.05). The group consisted of 6% black patients, compared with 35% for the entire cohort. Among the patients who had VitDd (25OHD < 20 ng/mL), ESSs was directly correlated with 25OHD in black (r = 0.48, p < 0.05) but not white patients. In black patients, mean ESSs in patients with VitDd were higher and 25OHD levels were lower p < 0.05).

CONCLUSIONS:

The results suggested the novel possibility that VitDd-related disease has a yet-to-be-identified mechanistic role in the presentation of sleepiness, sleep disorders, or both. Further research is needed to clarify the mechanism(s) involved in producing the complex relationships noted.

PMID:
23243403
PMCID:
PMC3501666
DOI:
10.5664/jcsm.2266
[Indexed for MEDLINE]
Free PMC Article
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