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Lung India. 2012 Oct;29(4):325-8. doi: 10.4103/0970-2113.102802.

Primary adenoid cystic carcinoma of the tracheobronchial tree: A decade-long experience at a health centre in Mexico.

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  • 1Department of Respiratory Physiology, National Institute of Respiratory Diseases (Instituto Nacional de Enfermedades Respiratorias, I.N.E.R.), Mexico City, Mexico.

Abstract

BACKGROUND:

Mexico's National Institute of Respiratory Diseases (NIRD) is a third-level national reference center. Primary adenoid cystic carcinoma (PACC) is an uncommon neoplastic disorder; hence improvements in the description of this disease are needed.

MATERIALS AND METHODS:

This is a retrospective clinical study based on all consecutive patients with pathological diagnoses of PACC seen at the NIRD between January 1, 2000 and December 31, 2009.

RESULTS:

We identified 9 cases of PACC (67% female) out of a total of 2,634 patients with lung cancer seen during the period analyzed. The mean age of those 9 patients was 41 years (IQR 36-57), and the frequency of PACC at our center was 0.3%. It is important to note that 67% of those patients had a history of smoking and that 6 of the 9 had the antecedent of previous exposure to biomass fuel smoke. Baseline arterial blood gas analyses revealed a median of 61 mmHg for pO(2) and 28.5 mmHg for pCO(2). Median FVC was 78%, while FEV(1) was 77% with an FEV(1) /FVC ratio of 78. Death occurred in 56% of cases, and the median survival time was 17 months (IQR 6-26) after the initial diagnosis.

CONCLUSIONS:

The frequency of tracheobronchial PACC among patients with lung cancer was similar to that previously reported (0.3%). According to our results, lung function has no specific phenotype in this disease; however, some abnormalities could be related to potential risk factors such as tobacco use and exposure to biomass fuel smoke.

KEYWORDS:

Fatal outcomes; prevalence; primary adenoid cystic carcinoma; respiratory function tests; tracheobronchial neoplasms

PMID:
23243344
PMCID:
PMC3519016
DOI:
10.4103/0970-2113.102802
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