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Clin Nucl Med. 2013 Jan;38(1):38-9. doi: 10.1097/RLU.0b013e31827082c4.

Effects of a ketogenic diet on brain metabolism in epilepsy.

Author information

1
Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark. korsholmk@gmail.com

Abstract

For a subpopulation of drug-resistant epilepsies, a ketogenic diet constitutes the treatment of choice. A ketogenic diet is a high-fat, low-protein, and low-carbohydrate diet, which induces ketosis. Despite the use in treatment of epilepsy since 1924, the clinical efficacy was not demonstrated in a controlled, randomized trial until 2008, showing its capability of reducing seizure frequency with more than 50%. However, the exact mechanism of this form of treatment is still unknown. We report here a patient with drug-resistant epilepsy on a ketogenic diet, where a brain 18F-FDG PET examination demonstrated a severely decreased uptake in the cerebral cortex bilaterally.

PMID:
23242044
DOI:
10.1097/RLU.0b013e31827082c4
[Indexed for MEDLINE]

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