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Nano Lett. 2013 Jan 9;13(1):79-84. doi: 10.1021/nl303500k. Epub 2012 Dec 19.

Orienting actin filaments for directional motility of processive myosin motors.

Author information

1
Department of Mechanical Engineering and Applied Mechanics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Abstract

To utilize molecular motors in manmade systems, it is necessary to control the motors' motion. We describe a technique to orient actin filaments so that their barbed ends point in the same direction, enabling same-type motors to travel unidirectionally. Myosin-V and myosin-VI were observed to travel, respectively, toward and away from the filaments' barbed ends. When both motors were present, they occasionally passed each other while "walking" in opposite directions along single actin filaments.

PMID:
23240631
DOI:
10.1021/nl303500k

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