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J Gen Virol. 2013 Apr;94(Pt 4):753-7. doi: 10.1099/vir.0.048348-0. Epub 2012 Dec 12.

Antiretroviral therapy promotes an inflammatory-like pattern of human T-cell lymphotropic virus type 1 (HTLV-1) replication in human immunodeficiency virus type 1/HTLV-1 co-infected individuals.

Author information

1
Université de Lyon 1, CNRS UMR5239, Oncovirology and Biotherapies, Centre Léon Bérard, Lyon, France.

Abstract

Upon antiretroviral therapy (ART) human immunodeficiency virus (HIV)/human T-cell lymphotropic virus type 1 (HTLV-1) co-infected individuals frequently develop neurological disorders through hitherto unknown mechanisms. Here, we show that effective anti-HIV ART increases HTLV-1 proviral load through a polyclonal integration pattern of HTLV-1 in both CD4(+) and CD8(+) T-cell subsets that is reminiscent of that typically associated with HTLV-1-related inflammatory conditions. These data indicate that preventing ART-triggered clonal expansion of HTLV-1-infected cells in co-infected individuals deserves investigation.

PMID:
23239567
DOI:
10.1099/vir.0.048348-0
[Indexed for MEDLINE]

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