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Nat Rev Immunol. 2013 Jan;13(1):46-57. doi: 10.1038/nri3344. Epub 2012 Dec 14.

The broad-spectrum antiviral functions of IFIT and IFITM proteins.

Author information

1
Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA. diamond@borcim.wustl.edu

Abstract

Over the past few years, several groups have identified new genes that are transcriptionally induced downstream of type I interferon (IFN) signalling and that inhibit infection by individual or multiple families of viruses. Among these IFN-stimulated genes with antiviral activity are two genetically and functionally distinct families--the IFN-induced protein with tetratricopeptide repeats (IFIT) family and the IFN-induced transmembrane protein (IFITM) family. This Review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM proteins, which explain their broad-spectrum activity against the replication, spread and pathogenesis of a range of human viruses.

PMID:
23237964
PMCID:
PMC3773942
DOI:
10.1038/nri3344
[Indexed for MEDLINE]
Free PMC Article

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