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Nat Rev Immunol. 2013 Jan;13(1):23-33. doi: 10.1038/nri3361. Epub 2012 Dec 14.

Mechanisms of T cell tolerance towards the allogeneic fetus.

Author information

1
Department of Pathology and NYU Cancer Institute, NYU School of Medicine, Langone Medical Center, 550 First Avenue, New York, New York 10016, USA. adrian.erlebacher@nyumc.org

Abstract

Work on the mechanisms of fetomaternal tolerance has undergone a renaissance in recent years, and the general outlines of a solution to this long-standing paradox of 'transplantation' immunology have come into view. Here, we discuss several mechanisms, recently described in mice, that either minimize the activation of maternal T cells with fetal or placental specificity, or minimize the possibility that such T cells, if activated, are able to harm the fetus. The T cell response to antigens expressed by the conceptus serves as a paradigm for the study of tissue-specific immune tolerance and is relevant to the pathogenesis of immune-mediated pregnancy complications.

PMID:
23237963
DOI:
10.1038/nri3361
[Indexed for MEDLINE]

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