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Biol Psychiatry. 2013 Apr 1;73(7):679-82. doi: 10.1016/j.biopsych.2012.10.030. Epub 2012 Dec 11.

Contribution of common genetic variants to antidepressant response.

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1
Institute of Psychiatry, King's College London, London, United Kingdom. katherine.tansey@kcl.ac.uk

Abstract

BACKGROUND:

Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this.

METHODS:

We estimate the contribution of common genetic variation to antidepressant response with Genome-Wide Complex Trait Analysis in a combined sample of 2799 antidepressant-treated subjects with major depressive disorder and genome-wide genotype data.

RESULTS:

We find that common genetic variants explain 42% (SE = .180, p = .009) of individual differences in antidepressant response.

CONCLUSIONS:

These results suggest that response to antidepressants is a complex trait with substantial contribution from a large number of common genetic variants of small effect.

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PMID:
23237317
DOI:
10.1016/j.biopsych.2012.10.030
[Indexed for MEDLINE]
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