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World J Gastroenterol. 2012 Dec 7;18(45):6690-2. doi: 10.3748/wjg.v18.i45.6690.

Malakoplakia of the esophagus caused by human papillomavirus infection.

Author information

1
Department of Pathology, Yunnan Province Second People's Hospital, Kunming 650021, Yunnan Province, China. appleyangyali@126.com

Abstract

Malakoplakia is a rare granulomatous disease probably caused by infection and characterized histologically by Michaelis-Gutmann bodies. We report a more rarely seen case esophageal malakoplakia in a 54-year-old woman. She presented with coughing while eating and drinking. Gastroscopy showed yellow nodules in the esophagus, and endoscopic ultrasonography showed a space-occupying lesion in the substratum of the esophageal mucosa. All findings highly resembled esophageal cancer. Histopathological examination finally indentified this space-occupying lesion as malakoplakia and not cancer. Immunohistochemistry showed that she had human papillomavirus (HPV) infection in the esophagus, which indicates that infection was responsible for the malakoplakia. This is believed to be the first case of malakoplakia in the esophagus, and more importantly, we established that HPV infection was the initiator of esophageal malakoplakia.

KEYWORDS:

Esophagus; Human papillomavirus infection; Malakoplakia; Michaelis-Gutmann bodies

PMID:
23236248
PMCID:
PMC3516212
DOI:
10.3748/wjg.v18.i45.6690
[Indexed for MEDLINE]
Free PMC Article
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