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Ann Burns Fire Disasters. 2012 Jun 30;25(2):66-73.

The efficacy of recombinant human activated protein C (rhAPC) vs antithrombin III (at III) vs heparin, in the healing process of partial-thickness burns: a comparative study.

Author information

1
J. Ioannovich Clinic of Plastic Surgery, Microsurgery and Burn Center, G. Gennimatas General Hospital, Athens, Greece.

Abstract

This is an experimental study regarding the positive effect of recombinant human activated protein C (rhAPC) in the healing process of partial-thickness burns, in comparison to antithrombin III and heparin. On a porcine model we induced superficial partial-thickness and deep partial-thickness burns and performed intravenous administration of the elements of study during the first 48 h. The progress of the condition of the injured tissues was evaluated by histopathological examination at specific time intervals. The results showed an improved healing response of the specimens treated with rhAPC compared to those treated with antithrombin III, heparin, and placebo.

KEYWORDS:

burns; healing; recombinant human activated protein C (rhAPC)

PMID:
23233823
PMCID:
PMC3506209

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