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Microbiologyopen. 2012 Dec;1(4):502-13. doi: 10.1002/mbo3.48. Epub 2012 Nov 28.

The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections.

Author information

1
Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, USA. liumo@ohsu.edu

Abstract

HlyU is a master regulator that plays an essential role in the virulence of the human pathogen Vibrio vulnificus. One of the most noteworthy characteristics of HlyU regulation in this organism is its positive control of the expression of the repeat-in-toxin (RtxA1) gene, one of the most important virulence factors accounting for the fulminating and damaging nature of V. vulnificus infections. In this work, we reviewed the latest studies of RtxA1 in this bacterium and highlight the mechanism of gene regulation of rtxA1 expression by HlyU under a broader gene regulatory network.

PMID:
23233275
PMCID:
PMC3535394
DOI:
10.1002/mbo3.48
[Indexed for MEDLINE]
Free PMC Article

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