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Int J Tuberc Lung Dis. 2013 Jan;17(1):67-75. doi: 10.5588/ijtld.12.0351.

Clinical characteristics of patients with tuberculosis-destroyed lung.

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Department of Internal Medicine, Seoul St. Mary's Hospital, Catholic University of Korea, Seoul, Korea.



Multicentre study.


To define the clinical characteristics of patients with tuberculosis (TB) destroyed lung due to past TB.


We reviewed patients with TB-destroyed lung between May 2005 and June 2011.


A total of 595 patients from 21 hospitals were enrolled. The mean age was 65.63 ± 0.47 (mean ± standard error); 60.5% were male. The mean number of lobes involved was 2.59 ± 0.05. Pleural thickening was observed in 54.1% of the patients. Mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV(1)), FEV(1)/FVC, bronchodilator response and number of exacerbations per year were respectively 2.06 ± 0.03 l (61.26% ± 0.79), 1.16 ± 0.02 l (49.05% ± 0.84), 58.03% ± 0.70, 5.70% ± 0.34, and 0.40 ± 0.04. The number of lobes involved was significantly correlated with FVC and FEV(1), and with the number of exacerbations per year. Use of long-acting muscarinic antagonists or long-acting beta-2 agonists plus inhaled corticosteroids resulted in bronchodilatory effects. Multivariable regression analysis showed that age, initial FEV(1) (%) and number of exacerbations during follow-up were independent factors affecting change in FEV(1).


Decreased lung function with exacerbation, and progressive decline of FEV(1) were observed in patients with TB-destroyed lung.

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