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Int J Tuberc Lung Dis. 2013 Jan;17(1):67-75. doi: 10.5588/ijtld.12.0351.

Clinical characteristics of patients with tuberculosis-destroyed lung.

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1
Department of Internal Medicine, Seoul St. Mary's Hospital, Catholic University of Korea, Seoul, Korea.

Abstract

SETTING:

Multicentre study.

OBJECTIVE:

To define the clinical characteristics of patients with tuberculosis (TB) destroyed lung due to past TB.

DESIGN:

We reviewed patients with TB-destroyed lung between May 2005 and June 2011.

RESULTS:

A total of 595 patients from 21 hospitals were enrolled. The mean age was 65.63 ± 0.47 (mean ± standard error); 60.5% were male. The mean number of lobes involved was 2.59 ± 0.05. Pleural thickening was observed in 54.1% of the patients. Mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV(1)), FEV(1)/FVC, bronchodilator response and number of exacerbations per year were respectively 2.06 ± 0.03 l (61.26% ± 0.79), 1.16 ± 0.02 l (49.05% ± 0.84), 58.03% ± 0.70, 5.70% ± 0.34, and 0.40 ± 0.04. The number of lobes involved was significantly correlated with FVC and FEV(1), and with the number of exacerbations per year. Use of long-acting muscarinic antagonists or long-acting beta-2 agonists plus inhaled corticosteroids resulted in bronchodilatory effects. Multivariable regression analysis showed that age, initial FEV(1) (%) and number of exacerbations during follow-up were independent factors affecting change in FEV(1).

CONCLUSION:

Decreased lung function with exacerbation, and progressive decline of FEV(1) were observed in patients with TB-destroyed lung.

PMID:
23232006
DOI:
10.5588/ijtld.12.0351
[Indexed for MEDLINE]
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