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Expert Opin Ther Pat. 2013 Feb;23(2):215-31. doi: 10.1517/13543776.2013.746314. Epub 2012 Dec 12.

Berberine and its derivatives: a patent review (2009 - 2012).

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1
National Institute of Pharmaceutical Education and Research, Department of Natural Products, Sector-67, S.A.S. Nagar, Punjab, 160062, India. ipsingh@niper.ac.in

Abstract

INTRODUCTION:

Berberine, a protoberberine alkaloid, and its derivatives exhibit a wide spectrum of pharmacological activities. It has been used in traditional Chinese medicine and Ayurvedic medicine and current research evidences support its use for various therapeutic areas.

AREAS COVERED:

This review covers the patents on therapeutic activities of berberine and its derivatives in the years between 2009 and 2012. An extensive search was done to collect the patent information using European Patent Office database and SciFinder. The therapeutic areas covered include cancer, inflammation, infectious diseases, cardiovascular, metabolic disorders, and miscellaneous areas such as polycystic ovary syndrome, allergic diseases, and so on.

EXPERT OPINION:

Berberine along with its derivatives or in combination with other pharmaceutically active compounds or in the form of formulations has applications in various therapeutic areas such as cancer, inflammation, diabetes, depression, hypertension, and various infectious areas. Berberine has demonstrated wide physiological functions and has great potential to give a multipotent drug if some inherent problems on poor bioavailability and solubility are taken care of. Additionally, polyherbal formulations with berberine-containing plants as major ingredients can be successfully developed.

PMID:
23231038
DOI:
10.1517/13543776.2013.746314
[Indexed for MEDLINE]
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