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RNA Biol. 2013 Jan;10(1):83-95. doi: 10.4161/rna.22547. Epub 2012 Dec 10.

RNA helicases in splicing.

Author information

1
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.

Abstract

In eukaryotic cells, introns are spliced from pre-mRNAs by the spliceosome. Both the composition and the structure of the spliceosome are highly dynamic, and eight DExD/H RNA helicases play essential roles in controlling conformational rearrangements. There is evidence that the various helicases are functionally and physically connected with each other and with many other factors in the spliceosome. Understanding the dynamics of those interactions is essential to comprehend the mechanism and regulation of normal as well as of pathological splicing. This review focuses on recent advances in the characterization of the splicing helicases and their interactions, and highlights the deep integration of splicing helicases in global mRNP biogenesis pathways.

KEYWORDS:

ATPase; DEAD-box; DEAH-box; DExD/H helicase; protein partners

PMID:
23229095
PMCID:
PMC3590240
DOI:
10.4161/rna.22547
[Indexed for MEDLINE]
Free PMC Article

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