Format

Send to

Choose Destination
See comment in PubMed Commons below
Biomark Med. 2012 Dec;6(6):813-9. doi: 10.2217/bmm.12.71.

The role of iron overload on oxidative stress in sickle cell anemia.

Author information

1
Department of Clinical & Toxicological Analysis of Federal University of Ceara, Fortaleza, Ceara, Brazil.

Abstract

Repeated blood transfusions in patients with sickle cell anemia (SCA) increases the risk of iron overload (IO), contributing to oxidative stress.

MATERIALS & METHODS:

Blood samples of 15 SCA patients without IO (group 1) and 15 SCA patients with IO (group 2) and 30 healthy individuals were collected to investigate oxidative stress. IO was categorized using repeated measures of serum ferritin. The biomarkers evaluated were plasmatic malondialdehyde (MDA), nitrite and erythrocyte catalase.

RESULTS:

MDA and nitrite were higher in group 2 than in group 1 and the healthy group (p < 0.001 for MDA and nitrite). Catalase presented lower in group 2 than group 1 and the healthy group (p < 0.001). We obtained a positive correlation between ferritin and MDA (r = 0.40; p < 0.02), and between ferritin and nitrite (r = 0359; p = 0.023).

CONCLUSION:

The results demonstrated that IO is an important risk factor for enhanced oxidative stress in SCA.

PMID:
23227847
DOI:
10.2217/bmm.12.71
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center