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Yao Xue Xue Bao. 2012 Sep;47(9):1187-92.

[Construction and application of natural products LC-MS-DS].

[Article in Chinese]

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State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center Beijing 100191, China.


To overcome the defects of current research methods of natural products, an LC-MS-DS that consisted of more than 600 natural products was constructed with HPLC-ESI-IT-MS/MS. The database searching results of LC-MS-DS were validated to be reliable, which indicated that LC-MS-DS could be successfully applied for the effective identification and target isolation of natural products. The study will provide an effective method for fast identification and efficient isolation of natural products.

[Indexed for MEDLINE]
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