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Theranostics. 2012;2(11):1040-53. doi: 10.7150/thno.4652. Epub 2012 Nov 5.

Image guided biodistribution and pharmacokinetic studies of theranostics.

Author information

1
Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA. hding@fiu.edu

Abstract

Image guided technique is playing an increasingly important role in the investigation of the biodistribution and pharmacokinetics of drugs or drug delivery systems in various diseases, especially cancers. Besides anatomical imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), molecular imaging strategy including optical imaging, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) will facilitate the localization and quantization of radioisotope or optical probe labeled nanoparticle delivery systems in the category of theranostics. The quantitative measurement of the bio-distribution and pharmacokinetics of theranostics in the fields of new drug/probe development, diagnosis and treatment process monitoring as well as tracking the brain-blood-barrier (BBB) breaking through by high sensitive imaging method, and the applications of the representative imaging modalities are summarized in this review.

KEYWORDS:

Image; antibody.; biodistribution; nanoparticles; pharmacokinetic; theranostics

PMID:
23227121
PMCID:
PMC3516836
DOI:
10.7150/thno.4652
[Indexed for MEDLINE]
Free PMC Article

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