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PLoS One. 2012;7(12):e49411. doi: 10.1371/journal.pone.0049411. Epub 2012 Dec 3.

Intake of Gnetum africanum and Dacryodes edulis, imbalance of oxidant/antioxidant status and prevalence of diabetic retinopathy in central Africans.

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1
Department of Ophthalmology, University of Kinshasa, Kinshasa, The Republic of Congo.

Abstract

OBJECTIVE:

To estimate the prevalence of DR and to correlate cardiometabolic, sociodemographic, and oxidant/antioxidant imbalance data to the prevalence of DR.

DESIGN:

This case-control study included type 2 DM (T2 DM) patients with DR (n = 66), T2 DM patients without DR (N = 84), and healthy controls (n = 45) without DR, in Kinshasa town. Diet, albuminemia, serum vitamins, and 8-isoprostane were examined.

RESULTS:

No intake of safou (OR = 2.7 95% CI 1.2-5.8; P = 0.014), low serum albumin <4.5 g/dL (OR-2.9 95% CI 1.4-5.9; P = 0.003), no intake of fumbwa (OR = 2.8 95% CI 1.2-6.5; P = 0.014), high 8-isoprostane (OR = 14.3 95% CI 4.5-46; P<0.0001), DM duration ≥ 5 years (OR = 3.8 95% CI 1.6-9.1; P = 0.003), and low serum vitamin C (OR = 4.5 95% CI 1.3-15.5; P = 0.016) were identified as the significant independent determinants of DR.

CONCLUSION:

The important role of oxidant/antioxidant status imbalance and diet is demonstrated in DR.

PMID:
23226496
PMCID:
PMC3513305
DOI:
10.1371/journal.pone.0049411
[Indexed for MEDLINE]
Free PMC Article
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