Format

Send to

Choose Destination
See comment in PubMed Commons below
Thorac Cardiovasc Surg. 2013 Apr;61(3):240-5. doi: 10.1055/s-0032-1322619. Epub 2012 Dec 6.

Gram-negative infection and bronchiectasis in lung transplant recipients with bronchiolitis obliterans syndrome.

Author information

1
Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, United States. hayes.705@osu.edu

Abstract

BACKGROUND:

Bronchiolitis obliterans syndrome (BOS) after lung transplantation manifests as a gradual decline in forced expiratory volume in 1 second. Bronchiectasis is often seen but occurs at variable rates with the underlying pathogenesis being unclear.

OBJECTIVE:

We completed a study to determine whether lower airway infection with gram-negative bacilli was associated with the development of bronchiectasis in lung transplant recipients with BOS.

METHODS:

A retrospective review of 17 lung transplant recipients (age: 28 ± 7 years, range: 13 to 40 years) in a patient population transplanted for cystic fibrosis (CF) 82% (14/17), bronchiolitis obliterans 12% (2/17), and sarcoidosis 6% (1/17) was completed. Each patient completed pulmonary function testing and underwent annual computed tomographic imaging of the chest for surveillance posttransplant at a single transplant center.

RESULTS:

Bronchiectasis was present in 70% (12/17) of patients whereas 94% (16/17) of patients had varying severity of BOS: 1 (n = 7), 2 (n = 3), and 3 (n = 6). All 12 patients with bronchiectasis had an allograft gram-negative rod infection and 92% (11/12) of them had BOS.

CONCLUSIONS:

The presence of bronchiectasis in lung transplant recipients with BOS was associated with a gram-negative bacterial airway infection of the allograft in a small cohort of predominately lung transplant recipients with CF.

PMID:
23225511
DOI:
10.1055/s-0032-1322619
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Georg Thieme Verlag Stuttgart, New York
    Loading ...
    Support Center