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Adv Exp Med Biol. 2013;961:137-45. doi: 10.1007/978-1-4614-4756-6_12.

Transcriptional regulation of ncx1 gene in the brain.

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1
Department of Neuroscience, Federico II University of Naples, Naples, Italy.

Abstract

The ubiquitous sodium-calcium exchanger isoform 1 (NCX1) is a -bidirectional transporter that plays a relevant role under physiological and pathophysiological conditions including brain ischemia by regulating intraneuronal Ca(2+) and Na(+) homeostasis. Although changes in ncx1 protein and transcript expression have been detected during stroke, its transcriptional regulation is still largely unexplored. Here, we reviewed our recent findings on several transcription factors including cAMP response element-binding protein (CREB), nuclear factor kappa B (NF-κB), and hypoxia-inducible factor-1 (HIF-1) in the control of the ncx1 gene expression in neuronal cells.

PMID:
23224876
DOI:
10.1007/978-1-4614-4756-6_12
[Indexed for MEDLINE]
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