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Neurogenetics. 2013 Feb;14(1):63-70. doi: 10.1007/s10048-012-0350-9. Epub 2012 Dec 9.

Comprehensive cytogenomic profile of the in vitro neuronal model SH-SY5Y.

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1
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, Oxford, UK.

Abstract

The widely studied SH-SY5Y human neuroblastoma cell line provides a classic example of how a cancer cell line can be instrumental for discoveries of broad biological and clinical significance. An important feature of the SH-SY5Y cells is their ability to differentiate into a functionally mature neuronal phenotype. This property has conferred them the potential to be used as an in vitro model for studies of neurodegenerative and neurodevelopmental disorders. Here, we present a comprehensive assessment of the SH-SY5Y cytogenomic profile. Our results advocate for molecular cytogenetic data to inform the use of cancer cell lines in research.

PMID:
23224213
PMCID:
PMC3569589
DOI:
10.1007/s10048-012-0350-9
[Indexed for MEDLINE]
Free PMC Article
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