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Int J Oral Sci. 2012 Dec;4(4):177-81. doi: 10.1038/ijos.2012.61. Epub 2012 Dec 7.

Molecular regulatory mechanism of tooth root development.

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1
Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Abstract

The root is crucial for the physiological function of the tooth, and a healthy root allows an artificial crown to function as required clinically. Tooth crown development has been studied intensively during the last few decades, but root development remains not well understood. Here we review the root development processes, including cell fate determination, induction of odontoblast and cementoblast differentiation, interaction of root epithelium and mesenchyme, and other molecular mechanisms. This review summarizes our current understanding of the signaling cascades and mechanisms involved in root development. It also sets the stage for de novo tooth regeneration.

PMID:
23222990
PMCID:
PMC3633063
DOI:
10.1038/ijos.2012.61
[Indexed for MEDLINE]
Free PMC Article
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