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Nucl Med Commun. 2013 Feb;34(2):98-107. doi: 10.1097/MNM.0b013e32835bd59d.

Single photon emission computed tomography/computed tomography in the evaluation of neuroendocrine tumours: a review of the literature.

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Department of Nuclear Medicine, Guy’s and St Thomas’ Hospital NHS Foundation Trust, Lambeth Palace Road, London SE1 7 EH, UK.


The scintigraphic investigation of neuroendocrine tumours such as carcinoids has depended on standard techniques such as I-metaiodobenzylguanidine and In-pentetreotide imaging. More recently, the use of PET techniques such as Ga-DOTATATE has been advocated. An alternative improved modality is high-quality single photon emission computed tomography/computed tomography (SPECT/CT), which has the advantages of better sensitivity and specificity and has shown improved localization in up to 60% of cases. These advantages are especially true for pancreatic and lymph node lesions. Overall, SPECT/CT can result in a change in clinical management in 25% of patients. Although it is possible to combine SPECT and CT performed at different time points, there is better anatomical localization and improved reporter confidence when SPECT and CT are performed simultaneously.

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