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J Mol Cell Cardiol. 2013 May;58:118-24. doi: 10.1016/j.yjmcc.2012.11.014. Epub 2012 Dec 5.

Ca²⁺ waves in the heart.

Author information

1
Department of Pharmacology, University of California, Davis, USA. ltizu@ucdavis.edu

Abstract

Ca(2+) waves were probably first observed in the early 1940s. Since then Ca(2+) waves have captured the attention of an eclectic mixture of mathematicians, neuroscientists, muscle physiologists, developmental biologists, and clinical cardiologists. This review discusses the current state of mathematical models of Ca(2+) waves, the normal physiological functions Ca(2+) waves might serve in cardiac cells, as well as how the spatial arrangement of Ca(2+) release channels shape Ca(2+) waves, and we introduce the idea of Ca(2+) phase waves that might provide a useful framework for understanding triggered arrhythmias.

PMID:
23220129
PMCID:
PMC3660086
DOI:
10.1016/j.yjmcc.2012.11.014
[Indexed for MEDLINE]
Free PMC Article

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