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Psychoneuroendocrinology. 2013 Aug;38(8):1251-8. doi: 10.1016/j.psyneuen.2012.11.008. Epub 2012 Dec 5.

Gene and protein alterations of FKBP5 and glucocorticoid receptor in the amygdala of suicide victims.

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Unidad de Neuropsicofarmacología Traslacional, Complejo Hospitalario Universitario de Albacete, C/Hermanos Falcó 37, Albacete 02006, Spain.


Recent reports suggest that FKBP5 gene and its corresponding FKBP5 protein play a relevant role in the regulation of anxiety and depression in animal models and human stress-related disorders. In the present study, FKBP5 and glucocorticoid receptor (GR) gene and protein expression were analyzed in the amygdala (AMY) of suicide victims (n=13 males, without clinical psychiatric history and non-treated with anxiolytic or antidepressant drugs) and its corresponding controls (n=13 males) by real-time PCR and Western blotting. The results revealed that FKBP5 and GR gene expression were significantly reduced in the AMY (-38% and -48%, respectively) of suicide victims compared with controls. Interestingly, FKBP5 and GR protein expression were also significantly decreased (-41% and -42%, respectively) in the AMY of suicide victims compared with controls. These results suggest that the FKBP5 plays a relevant role in human emotional responses and suggest this receptor as a new promising target in the treatment of suicide behavior.

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