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J Pain Symptom Manage. 2012 Dec;44(6 Suppl):S4-14. doi: 10.1016/j.jpainsymman.2012.08.013.

Opioid therapies and cytochrome p450 interactions.

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1
The Pain Management and Wellness Center, Englewood Hospital and Medical Center, Englewood, New Jersey 07631, USA. healthmd@optonline.net

Abstract

Adverse drug reactions are common and associated with substantial economic and human costs. Particularly among older adult populations, preventable adverse drug reactions are often caused by drug-drug interactions. All analgesics have side effect profiles and many have known drug-drug interactions. Opioids are recognized as a necessary option for managing moderate-to-severe pain, yet many opioid side effects can be enhanced by metabolic interactions within the liver, involving other drugs, diseases, or genetics.

[Indexed for MEDLINE]

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