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Cell. 2012 Dec 7;151(6):1163-7. doi: 10.1016/j.cell.2012.11.012.

Cleaning up: ER-associated degradation to the rescue.

Author information

1
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. jbrodsky@pitt.edu

Abstract

All cellular proteins are subject to quality control "decisions," which help to prevent or delay a myriad of diseases. Quality control within the secretory pathway creates a special challenge, as aberrant polypeptides are recognized and returned to the cytoplasm for proteasomal degradation. This process is termed endoplasmic-reticulum (ER)-associated degradation (ERAD).

PMID:
23217703
PMCID:
PMC3521611
DOI:
10.1016/j.cell.2012.11.012
[Indexed for MEDLINE]
Free PMC Article

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