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Cell. 2012 Dec 7;151(6):1161-2. doi: 10.1016/j.cell.2012.11.031.

Modeling transcriptome dynamics in a complex world.

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1
Departments of Medicine and Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.

Abstract

An accurate prediction of how extrinsic stimuli influence changes in gene expression has been challenging. In this issue, Nagano and colleagues successfully model genome-wide mRNA expression changes under variable environmental conditions in rice, raising hopes that scientists will soon be able to predict genome-wide transcriptional responses in a variety of organisms in uncontrolled real-world settings.

PMID:
23217702
DOI:
10.1016/j.cell.2012.11.031
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