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Virology. 2013 Jan 5;435(1):141-56. doi: 10.1016/j.virol.2012.09.023.

Snapshots: chromatin control of viral infection.

Author information

1
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.

Abstract

Like their cellular host counterparts, many invading viral pathogens must contend with, modulate, and utilize the host cell's chromatin machinery to promote efficient lytic infection or control persistent-latent states. While not intended to be comprehensive, this review represents a compilation of conceptual snapshots of the dynamic interplay of viruses with the chromatin environment. Contributions focus on chromatin dynamics during infection, viral circumvention of cellular chromatin repression, chromatin organization of large DNA viruses, tethering and persistence, viral interactions with cellular chromatin modulation machinery, and control of viral latency-reactivation cycles.

PMID:
23217624
PMCID:
PMC3531885
DOI:
10.1016/j.virol.2012.09.023
[Indexed for MEDLINE]
Free PMC Article

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