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Cell Stem Cell. 2012 Dec 7;11(6):732-4. doi: 10.1016/j.stem.2012.11.012.

Utf1: Goldilocks for ESC bivalency.

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Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Sacramento, CA 95817, USA.


Recently in Cell, Jia et al. (2012) reported novel Utf1-controlled mechanisms of maintaining pluripotency and self-renewal in embryonic stem cells (ESCs). Utf1 buffers bivalent gene expression by competitive binding with polycomb repressive complex 2 and initiation of mRNA degradation.

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