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Cell Metab. 2012 Dec 5;16(6):691-2. doi: 10.1016/j.cmet.2012.11.009.

Is hyperinsulinemia required to develop overeating-induced obesity?

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  • 1Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA.


Type 2 diabetes is characterized by insulin resistance, and the hyperinsulinemia commonly observed in patients is thought to be a compensatory response. Yet it has been difficult to disentangle cause and effect. Mehran et al. (2012) provide genetic evidence that a reduction of insulin secretion prevents high-fat feeding-induced obesity.

Copyright © 2012 Elsevier Inc. All rights reserved.

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