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Cell Metab. 2012 Dec 5;16(6):687-8. doi: 10.1016/j.cmet.2012.11.010.

Linking glycogen and senescence in cancer cells.

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1
Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.

Abstract

Glycogen metabolism operates as an alternative energy source, enabling cell growth under conditions of metabolic stress. Favaro et al. (2012) now demonstrate that in hypoxic cancer cells, depletion of liver glycogen phosphorylase causes glycogen accumulation, leading to oxidative stress, induction of senescence, and impaired tumor growth in vivo.

PMID:
23217251
DOI:
10.1016/j.cmet.2012.11.010
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