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Crit Rev Immunol. 2012;32(2):97-126.

Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens.

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Institute of Immunology and Infection Research, The University of Edinburgh, Edinburgh, UK.


Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in tumor medicine, as many tumors express specific tumor associated antigens that are recognized by the adaptive immune system. CD8 T cells have direct cytolytic activity against tumor cells, and CD4 T cells mount a variety of responses that have important influences on tumor growth. We discuss how individual T-cell subsets contribute to antitumor responses and the goals and problems associated with generating and/or maintaining effective multifunctional T-cell responses to provide long-term protection against tumors.

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