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J Org Chem. 2013 Jan 18;78(2):320-7. doi: 10.1021/jo302127d. Epub 2012 Dec 24.

Tag-assisted liquid-phase peptide synthesis using hydrophobic benzyl alcohols as supports.

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1
Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.

Abstract

A soluble tag-assisted liquid-phase peptide synthesis was successfully established based on simple hydrophobic benzyl alcohols, which can be easily prepared from naturally abundant materials. Excellent precipitation yields can be obtained at each step, combining the best properties of solid-phase and liquid-phase techniques. This approach can also be applied efficiently to fragment couplings, allowing chemical synthesis of several bioactive peptides.

PMID:
23215232
DOI:
10.1021/jo302127d
[Indexed for MEDLINE]
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