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Org Lett. 2012 Dec 21;14(24):6366-9. doi: 10.1021/ol3031704. Epub 2012 Dec 6.

Substitution effect on the one- and two-photon sensitivity of DMAQ "caging" groups.

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1
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes, France.

Abstract

The systematic SAR study of a "caging" group showed a strong influence of the position of the donor dimethylamino group on the efficiency of photolysis of the DMAQ (2-hydroxymethylene-(N,N-dimethylamino)quinoline) caged acetate under one-photon near-UV or two-photon near-IR excitation. Photorelease of l-glutamate by the most efficient 8-DMAQ derivative strongly and efficiently activated glutamate receptors, generating large, fast rising responses similar to those elicited by glutamate photoreleased from the widely used MNI-caged glutamate.

PMID:
23214948
DOI:
10.1021/ol3031704
[Indexed for MEDLINE]

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