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Arch Pharm Res. 2012 Nov;35(11):1895-901. doi: 10.1007/s12272-012-1105-8. Epub 2012 Dec 4.

Design, synthesis, and biological evaluation of novel 1, 2, 4-triazole derivatives as antifungal agent.

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1
Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Guohe Road 325, Shanghai 200433, China.

Abstract

A series of novel 1, 2, 4-triazole derivatives (9a-p) have been designed and synthesized as the potential antifungal agents. All compounds were characterized by (1)H-NMR, (13)C-NMR, and LCMS. Their antifungal activities against seven human pathogenic fungi were evaluated in vitro by measuring the minimal inhibitory concentrations. Most of the tested compounds were found to be more potent against Candida albicans than the control drug fluconazole.

PMID:
23212630
DOI:
10.1007/s12272-012-1105-8
[Indexed for MEDLINE]
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