Format

Send to

Choose Destination
See comment in PubMed Commons below
Heredity (Edinb). 2013 Mar;110(3):259-66. doi: 10.1038/hdy.2012.81. Epub 2012 Dec 5.

The origin and functional transition of P34.

Author information

1
State Key Laboratory of Crop Genetics and Germplasm Enhancement, Department of Crop Genetics and Breeding, College of Agriculture, Nanjing Agricultural University, Nanjing, China.

Abstract

P34, a storage protein and major soybean allergen, has undergone a functional transition from a cysteine peptidase to a syringolide receptor. An exploration of the evolutionary mechanism of this functional transition is made. To identify homologous genes of P34, syntenic network was constructed using syntenic relationships from the Plant Genome Duplication Database. The collected homologous genes, along with SPE31, a highly homologous protein to P34 from the seeds of Pachyrhizus erosus, were used to construct a phylogenetic tree. The results show that multiple gene duplications, exon shuffling and following granulin domain loss and some critical point mutations are associated with the functional transition. Although some tests suggested the existence of positive selection, the possibility that random fixation under relaxation of purifying selection results in the functional transition is also supported. In addition, the genes Glyma08g12340 and Medtr8g086470 may belong to a new group within the papain family.

PMID:
23211789
PMCID:
PMC3668652
DOI:
10.1038/hdy.2012.81
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center