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J Am Med Dir Assoc. 2013 Apr;14(4):265-9. doi: 10.1016/j.jamda.2012.10.018. Epub 2012 Dec 1.

Prevalence and associations of the use of proton-pump inhibitors in nursing homes: a cross-sectional study.

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1
Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France. philipebarreto81@yahoo.com.br

Abstract

OBJECTIVES:

Very scarce information is available about the use of proton-pump inhibitors (PPI) in nursing homes (NH). This study investigated the factors associated with PPI use among NH residents.

DESIGN:

Cross-sectional

SETTING:

One hundred seventy-five NHs in Midi-Pyrénées region, South-Western France.

PARTICIPANTS:

Data was collected for 6275 NH residents. Participants (73.7% women) were aged 86 years (± 8.2).

MEASUREMENTS:

NH staff sent participants' drug prescriptions to research team; they also recorded information on residents' health characteristics. A binary logistic regression was performed on PPI use.

RESULTS:

PPI use was highly prevalent (n = 2 370, ie, 37.8%). Whilst peptic ulcer (OR 4.741; 95% CI 3.647-6.163) and nonsteroidal anti-inflammatory drugs (OR 2.124; 95% CI 1.528-2.951) were important indicators of PPI use, they explained just a small fraction of PPI prescriptions; most prescriptions were probably inappropriately related to a general condition of health vulnerability, reflected by polypharmacy and comorbidities.

CONCLUSIONS:

Vulnerable people take PPIs more often in NHs. Physicians must be aware about the health risks possibly induced by inappropriate PPI use when prescribing these drugs for NH residents.

PMID:
23211534
DOI:
10.1016/j.jamda.2012.10.018
[Indexed for MEDLINE]
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