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PLoS One. 2012;7(11):e49792. doi: 10.1371/journal.pone.0049792. Epub 2012 Nov 28.

Drug-eluting fibers for HIV-1 inhibition and contraception.

Author information

1
Department of Bioengineering, University of Washington, Seattle, WA, USA.

Abstract

Multipurpose prevention technologies (MPTs) that simultaneously prevent sexually transmitted infections (STIs) and unintended pregnancy are a global health priority. Combining chemical and physical barriers offers the greatest potential to design effective MPTs, but integrating both functional modalities into a single device has been challenging. Here we show that drug-eluting fiber meshes designed for topical drug delivery can function as a combination chemical and physical barrier MPT. Using FDA-approved polymers, we fabricated nanofiber meshes with tunable fiber size and controlled degradation kinetics that facilitate simultaneous release of multiple agents against HIV-1, HSV-2, and sperm. We observed that drug-loaded meshes inhibited HIV-1 infection in vitro and physically obstructed sperm penetration. Furthermore, we report on a previously unknown activity of glycerol monolaurate (GML) to potently inhibit sperm motility and viability. The application of drug-eluting nanofibers for HIV-1 prevention and sperm inhibition may serve as an innovative platform technology for drug delivery to the lower female reproductive tract.

PMID:
23209601
PMCID:
PMC3509119
DOI:
10.1371/journal.pone.0049792
[Indexed for MEDLINE]
Free PMC Article

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