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Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12). pii: a013177. doi: 10.1101/cshperspect.a013177.

Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation.

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1
Metabolic Research Laboratories, University of Cambridge, and NIHR Cambridge Biomedical Research Centre, Addenbrookes Hospital, Cambridge CB2 0QQ, United Kingdom. dr360@medschl.cam.ac.uk

Abstract

The flux of newly synthesized proteins entering the endoplasmic reticulum (ER) is under negative regulation by the ER-localized PKR-like ER kinase (PERK). PERK is activated by unfolded protein stress in the ER lumen and inhibits new protein synthesis by the phosphorylation of translation initiation factor eIF2α. This homeostatic mechanism, shared by all animal cells, has proven to be especially important to the well-being of professional secretory cells, notably the endocrine pancreas. PERK, its downstream effectors, and the allied branches of the unfolded protein response intersect broadly with signaling pathways that regulate nutrient assimilation, and ER stress and the response to it have been implicated in the development of the metabolic syndrome accompanying obesity in mammals. Here we review our current understanding of the cell biology underlying these relationships.

PMID:
23209157
PMCID:
PMC3504434
DOI:
10.1101/cshperspect.a013177
[Indexed for MEDLINE]
Free PMC Article
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